Patrick Kerzic, PhD, DABT
Dr. Patrick Kerzic is a board-certified toxicologist (DABT) with extensive experience in the design, conduct, and analysis of mechanistic and human subject research studies as well as human health risk assessment. Dr. Kerzic completed his PhD in Toxicology at the University of Colorado Health Sciences Center and post-doctoral training at Johns Hopkins University School of Medicine. His doctoral research examined the effects of benzene metabolites on signaling molecules, and their ability to alter survival and differentiation in bone marrow cells.
Prior to coming to CTEH, Dr. Kerzic served as a Staff Toxicologist with the California Environmental Protection Agency, where he oversaw human health risk assessment activities for over 100 sites contaminated with solvents, metals, and other hazardous materials. He also served as a writer and reviewer for the Safer Consumer Products program, which aims to encourage substitution of hazardous compounds with safer alternatives.
Dr. Kerzic has served as Scientific Director for a laboratory conducting research and clinical studies into diseases of the blood including leukemia and lymphoma, where he oversaw molecular biology and toxicology programs.
Throughout his career, Dr. Kerzic has provided technical and litigation support for a variety of projects including court cases involving benzene and other solvents, and assistance to companies and industry associations facing challenges regarding potential hazards caused by their products. He has published more than 35 abstracts and peer-reviewed papers in the fields of toxicology and hematology, and is a past or current member of the American Society of Hematology, the International Society for Experimental Hematology and Stem Cells, and the Society of Toxicology.
- Ph.D., Toxicology, University of Colorado Health Sciences Center, Denver, CO
- B.S., Pharmacology, University of California at Santa Barbara, Santa Barbara, CA
- Society of Toxicology (SOT)
- Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Distribution of chromosome breakpoints in benzene-exposed and unexposed AML patients
- Hospital-Based Case-Control Study of MDS Subtypes and Benzene Exposure in Shanghai
- Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes
- Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum
- Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy-related disease
- Peripheral blood effects in benzene-exposed workers. Chem Biol Interact
- Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers
- A polymorphism confers susceptibility to the development of myelodysplasia in individuals with previous chronic exposure to benzene
- PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34(+) hematopoietic progenitor cells
- Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations
- Chronic exposure to benzene results in a unique form of dysplasia
- P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing
- Hydroquinone modulates the GMCSF signaling pathway in TF-1 cells
- Inhibition of NF-kB byhydroquinone sensitizes human bone marrow progenitor cells to TNF-a-induced apoptosis
- Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis
- Increased expansion and differentiation of cord blood products using a two-step expansion culture
- A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans
- Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential
- An analysis of the effects of combined treatment with rmGM-CSF and PEG-rHuMGDF in murine bone marrow transplant recipients