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Michael Lumpkin, PhD, DABT

Senior Toxicologist

Dr. Michael Lumpkin is a board-certified toxicologist with experience in dose reconstruction, chemical dose-response assessment, physiologically-based pharmacokinetic (PBPK) modeling, chemical emergency response, product stewardship and safety assessments, and litigation support. Michael has developed, critiqued and applied PBPK models for volatile organic compounds (VOCs), metals, pesticides and bioterrorism agents for USEPA, CDC and DOD, for use in regulatory standard support and emergency planning. He has developed a framework and performed safety assessments of dietary supplement products. He has coauthored numerous peer-reviewed hazard assessments for USEPA and the Agency for Toxic Substances and Disease Registry (ATSDR). He has provided critical reviews and analyses of toxicology data for numerous compounds, including formaldehyde, PAHs, inhaled dust and perchlorates. Michael has provided analyses of human and animal study data in support of new drugs and medical device applications, and has designed and performed occupational exposure reconstructions for VOCs and diisocyanates using laboratory simulations. He has developed novel occupational exposure limits for pharmaceutical and industrial chemicals. Michael has served on ad hoc federal grant review committees and as a peer reviewer for toxicology journals, and has lectured in graduate courses and emergency responder seminars for inhalation toxicology and risk assessment. He is a member of the Society of Toxicology and is certified as a Diplomate of the American Board of Toxicology. 

Education

  • Ph.D., Toxicology, University of Georgia, Athens, Georgia
  • B.S., Biochemistry, University of Georgia, Athens, Georgia

Registrations & Certifications

  • Diplomate, American Board of Toxicology
  • 40 Hour HAZWOPER
  • 8 Hour HAZWOPER Supervisor
  • TWIC Clearance
  • Former Firefighter I (NFPA 1001), National Board on Fire Service Professional Qualifications

Past or Current Professional Affiliations

  • Member, Society of Toxicology
  • Councilor, Risk Assessment Specialty Section of the Society of Toxicology
  • President, Southeastern Regional Chapter of the Society of Toxicology

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Phone: (501) 801-8500


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Publications

  • Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling
  • DMAA as a Dietary Ingredient
  • Pharmacokinetic data distinguish abusive versus dietary supplement uses of 1,3-dimethylamylamine
  • Acrolein environmental levels and potential for human exposure
  • Acrolein health effects
  • PBPK Modeling on the Metabolic Interactions of Carbon Tetrachloride and Tetrachloroethylene
  • Plasma Binding of Trichloroacetic Acid in Mice, Rats, and Humans under Cancer Bioassay and Environmental Conditions
  • The Pharmacokinetic of Perchlorate and its Effect on the Hypothalamus/Pituitary-Thyroid Axis
  • Chlorinated Hydrocarbons. In Hamilton and Hardy’s Industrial Toxicology
  • Other Halogenated Hydrocarbons

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North Little Rock, AR 72118
Ph: 501.801.8500
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